IGF-1 LR3 – 1mg

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a recombinant analog of human IGF-1 engineered with a 13-amino-acid N-terminal extension and an arginine substitution at position 3. These modifications significantly reduce IGF-binding protein (IGFBP) affinity, enhancing receptor accessibility and extending activity in vitro. Mechanistic findings indexed under PMID: 1318405 describe the altered receptor kinetics and potent IGF-1R activation profile associated with LR3 variants.

In controlled laboratory environments, IGF-1 LR3 is utilized to examine IGF-1 receptor signaling, PI3K/Akt and MAPK pathway modulation, cellular proliferation responses, receptor-binding kinetics, and biochemical processes influenced by reduced IGFBP sequestration. Its enhanced potency supports applications in pathway-mapping assays, receptor-stimulation models, and growth factor–dependent biochemical research.

The lyophilized research-grade peptide ensures reproducibility, stability, and consistent purity for laboratory assays requiring reliable IGF-1 analog performance.

Important Information About This Research Product:

• Your vials are not empty — the lyophilized material collects at the bottom.
• All products arrive as lyophilized powder requiring reconstitution.
• Bacteriostatic water is not supplied.
• Store in a cool, dry environment — short-term at 4°C, long-term at −20°C.
• This material is strictly for laboratory research use only. No instructions for reconstitution, dosing, or administration can be provided.